mtDNA Variation and Aging

Overview of the role of the mitochondrion in the aging process, and various theories about the evolution of senescence.

Discuss looking for genetic influences on longevity in human populations, including telomerase. Seeking more comprehensive explanation for process of aging in humans, and other organisms by extension.

A Summary of the Effects of Aging on Mitochondrial OXPHOS Function

Image source: Cedikova et al. 2016. Multiple roles of mitochondria in the aging process. Physiol. Res. (Suppl. 5): S519-S531.

Description of collaboration with Astanand Jugessur NIPH and others

mtDNA Variation and Aging in Norway

Image source:

Laboratory of Molecular Anthropology
University of Pennsylvania
421 University Museum
3260 South Street
Philadelphia, PA 19104-6398, USA
Tel: 215-573-2656