Mitochondrial Diseases
We characterized mtDNA and nuclear DNA-based OXPHOS diseases in Russian and Ukrainian populations to better understand the etiology and mechanisms of the expression of mitochondrial disorders in population-specific genetic backgrounds.
Mitochondrial Diseases in Ukraine
Collaboration with Dr. Elena Y. Grechanina from the Kharkiv Medical Institute to study pediatric mitochondrial diseases in Ukraine.
![provinces-of-ukraine-map](https://schurrfire.com/wp-content/uploads/2021/07/provinces-of-ukraine-map-1024x697.png)
Political Map of Ukraine with Provinces
Source: https://www.worldatlas.com/maps/ukraine
![Schurr Meets Avakov](https://schurrfire.com/wp-content/uploads/2021/07/Schurr-Meets-Avakov-1024x683.jpg)
Dr. T.G. Schurr Meets Governor Avakov in Kharkiv
![Grechanina and Avakov](https://schurrfire.com/wp-content/uploads/2021/07/Grechanina-and-Avakov-1024x683.jpg)
Dr. E.Y. Grechanina Talks with Governor Avakov
![Discussing the Project](https://schurrfire.com/wp-content/uploads/2021/07/Discussing-the-Project-1024x755.jpg)
Discussing the Mitochondrial Disease Research Project in Kharkiv
![Kharkiv Medical Institute](https://schurrfire.com/wp-content/uploads/2021/07/Kharkiv-Medical-Institute-1024x681.jpg)
Kharkiv Medical Institute
Photo credit: T.G. Schurr
![Katya & Student at Work](https://schurrfire.com/wp-content/uploads/2021/07/Katya-Student-at-Work-1024x681.jpg)
Dr. Ekaterina Grechanina Instructing a Student
Photo credit: T.G. Schurr
![TGS & Doctors](https://schurrfire.com/wp-content/uploads/2021/07/TGS-Doctors.jpg)
T.G. Schurr with Kharkiv Medical Institute Doctors
![Vlada on the Phone](https://schurrfire.com/wp-content/uploads/2021/07/Vlada-on-the-Phone-681x1024.jpg)
Vlada Gusar
Photo credit: T.G. Schurr
During our visit in 2008, we visited Kharkiv National Medical University, and explored its museum, library and
![Харківський_медичний_унівеситет](https://schurrfire.com/wp-content/uploads/2021/07/Харківський_медичний_унівеситет-1024x706.jpg)
Kharkiv National Medical University
Image source: https://en.wikipedia.org/wiki/Kharkiv_National_Medical_University
![KMS Museum 1](https://schurrfire.com/wp-content/uploads/2021/07/KMS-Museum-1-1024x681.jpg)
Kharkiv National Medical University Museum
Photo credit: T.G. Schurr
![Old Med Student Desk](https://schurrfire.com/wp-content/uploads/2021/07/Old-Med-Student-Desk-1024x681.jpg)
Desk and Study Materials for 1919 Medical Students
Photo credit: T.G. Schurr
During our initial visit in 2006, we had a chance to explore the city of Kharkiv, despite the snowy weather. The following photos provide a brief visual guide to this historic city in Ukraine.
![Artists Selling Work](https://schurrfire.com/wp-content/uploads/2021/07/Artists-Selling-Work-1024x669.jpg)
Artists Selling Paintings in City Park Winter 2006
Photo credit: T.G. Schurr
![Orthodox Church Kharkiv](https://schurrfire.com/wp-content/uploads/2021/07/Orthodox-Church-Kharkiv-1024x669.jpg)
Cathedral of the Assumption of the Blessed Virgin Mary
Photo credit: T.G. Schurr
![Kharkiv Cultural Center](https://schurrfire.com/wp-content/uploads/2021/07/Kharkiv-Cultural-Center-1024x669.jpg)
Kharkiv Center of Arts
Photo credit: T.G. Schurr
![Pushkin Theater](https://schurrfire.com/wp-content/uploads/2021/07/Pushkin-Theater-1024x669.jpg)
Pushkin Theater
Photo credit: T.G. Schurr
![Downtown Kharkiv](https://schurrfire.com/wp-content/uploads/2021/07/Downtown-Kharkiv-1024x669.jpg)
A View of Downtown Kharkiv
Photo credit: T.G. Schurr
![State Radio Station](https://schurrfire.com/wp-content/uploads/2021/07/State-Radio-Station-1024x669.jpg)
State Radio Station
Photo credit: T.G. Schurr
![Annunciation Cathedral](https://schurrfire.com/wp-content/uploads/2021/07/Annunciation-Cathedral-1-722x1024.jpg)
Annunciation Cathedral
Photo credit: T.G. Schurr
Publications
Schurr TG, Grechanina YB, Gusar VA, Grechanina EY, Zhadanov SI. 2012. Mitochondrial diseases in Ukraine: Role of mtDNA mutations in complex clinical syndrome and neurodegenerative diseases. J Ukr Acad Med Sci [in Ukrainian].
Gusar VA, Grechanina JB, Zhadanov SI, Schurr TG, Grechanina YB, Fadeeva AL. 2011. Visualizing exact mitochondrial DNA mutations through the method of restriction analysis. Clinical Genetics 1-2: 95-111 [in Ukrainian].
Zhadanov SI, Grechanina EY, Grechanina YuB, Gusar VA, Fedoseeva NP, Schurr TG, Doronin BM. 2008. Clinical complex syndromes: Importance of genetic screening of mtDNA mutations in the diagnosis of mitochondrial neurodegenerative syndromes. Zh Nevrol Psikhiatr Im S S Korsakova 108(5): 80-83 [in Ukrainian].
Zhadanov SI, Grechanina EY, Grechanina YB, Gusar VA, Fedoseeva NP, Lebon S, Münnich SA, Schurr TG. 2007. Fatal manifestation of a de novo ND5 mutation: Implication for the pathogenetic mechanisms of ND5 gene defects. Mitochondrion 7(4): 260-266.
Zhadanov SI, Grechanina EY, Grechanina YB, Gusar VA, Fedoseeva NP, Schurr TG. 2006. Studying mitochondrial diseases in the Ukraine: The role of de novo ND5 mutations and pathogenic mechanisms of genetic defects in the ND5 gene. J Ukr Acad Med Sci 12(3): 443-456 [in Ukrainian].
Zhadanov SI, Atamanov VV, Zhadanov NI, Schurr TG. 2006. De novo COX2 mutation in a LHON family of Caucasian origin: Implication for the role of mtDNA polymorphism in human pathology. J Hum Genet 51(3): 161-170.
Zhadanov SI, Atamanov VV, Zhadanov NI, Oleinikov OV, Osipova LP, Schurr TG. 2005. A novel mtDNA ND6 gene mutation associated with LHON in a Caucasian family. Biochem Biophys Res Comm 332: 1115-1121.
Wallace DC, Stugard C, Murdock D, Schurr TG, Brown MD. 1997. Ancient mitochondrial DNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations. Proc Natl Acad Sci USA 94(26): 14900-14905.
Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AMS, Elsas, II, LJ, Nikoskelainen EK. 1988. Mitochondrial DNA mutation associated with Leber’s Hereditary Optic Neuropathy. Science 242(4884): 1427-1430.
Laboratory of Molecular Anthropology
University of Pennsylvania
421 University Museum
3260 South Street
Philadelphia, PA 19104-6398, USA
Tel: 215-573-2656
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